匹诺塞林的神经保护作用机制研究进展

王玉敏, 葛永利, 赵丽楠, 赵伟丽, 杜冠华, 王洪权

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (4) : 245-248.

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中国药学杂志
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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (4) : 245-248. DOI: 10.11669/cpj.2018.04.001
综述

匹诺塞林的神经保护作用机制研究进展

  • 王玉敏1a, 葛永利2, 赵丽楠1b, 赵伟丽1c, 杜冠华3*, 王洪权1c,3*
作者信息 +

Recent Progress in Understanding the Mechanism of Neuroprotective Effect of Pinocembrin

  • WANG Yu-min1a, GE Yong-li2, ZHAO Li-nan1b, ZHAO Wei-li1c, DU Guan-hua3*, WANG Hong-quan1c,3*
Author information +
文章历史 +

摘要

匹诺塞林(pinocembrin)化学名为5,7-二羟基黄烷酮,是从蜂蜜,蜂胶,姜,野生马郁兰等提取的一种黄酮类化合物,具有抗氧化、抗炎、血管舒张等多方面的作用。其在体内外具有广泛的神经保护作用。笔者就匹诺塞林在脑缺血和神经退行性疾病中的神经保护作用进行了综述,总结了其在动物及细胞实验水平的药理学活性、可能的神经保护作用机制。

Abstract

Pinocembrin (5, 7-dihydroxyflavanone), a flavanone, is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown to have neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these a variety of pharmacological activities, pinocembrin has potential as a drug to treat ischemic stroke and neurodegenerative disease. Its pharmacologic characteristics are summarized and mechanistic details relating preclinical studies are discusses.

关键词

匹诺塞林 / 脑卒中 / 神经退行性疾病 / 神经保护

Key words

pinocembrin / stroke / neurodegenerative disease / neuroprotection

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王玉敏, 葛永利, 赵丽楠, 赵伟丽, 杜冠华, 王洪权. 匹诺塞林的神经保护作用机制研究进展[J]. 中国药学杂志, 2018, 53(4): 245-248 https://doi.org/10.11669/cpj.2018.04.001
WANG Yu-min, GE Yong-li, ZHAO Li-nan, ZHAO Wei-li, DU Guan-hua, WANG Hong-quan. Recent Progress in Understanding the Mechanism of Neuroprotective Effect of Pinocembrin[J]. Chinese Pharmaceutical Journal, 2018, 53(4): 245-248 https://doi.org/10.11669/cpj.2018.04.001
中图分类号： R741.05   

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基金

国家自然科学基金资助项目(81260196,81450036);中国博士后科学基金(2015M570974);内蒙古自然科学基金资助项目(2015BS0812,2017MS0867,2017MS0868); 内蒙古自治区高等学校科学研究项目资助(NJZY234);内蒙古自治区高等学校青年科技英才支持计划资助(NJYT-17-B23);“草原英才”工程计划资助项目;“内蒙古自治区青年创新人才”计划资助项目;内蒙古自治区新世纪321人才工程计划资助项目
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